A fatal medication error

A 75-year-old woman died at Vanderbilt University Medical Center after receiving intravenous vecuronium, a drug that causes muscle paralysis, instead of Versed, a sedative.

Here’s what happened.

She had been recovering well from an intraparenchymal brain hematoma after a fall. While awaiting a full body positron emission tomography (PET) scan in the radiology department, the patient said she was anxious about being in the machine because she was claustrophobic.

A doctor ordered Versed 2 mg IV in the electronic medical record at 2:47 PM. Two minutes later, the pharmacy verified the order. The radiology department staff said they could not give the medication because they were very busy and the patient would need to be monitored.

So nurse A, who was functioning as the “help all” nurse was asked by the patient’s nurse, nurse B, to go to radiology and give the medication. At 2:59 PM, nurse A went to the automated dispensing cabinet (ADC) and searched for Versed in the patient’s profile. When she couldn’t find the drug listed, she selected the “override” setting to search for the drug. She entered the first two letters of the drug, VE, and clicked on the first medication that popped up.

More proof medical error is not the third leading cause of death

Over the last 20 years, estimates of the number of deaths caused by medical error have risen from 44,000-98,000 in 1999 [1] all the way up to 440,000 [2] and 251,000 [3]. Despite my efforts [4, 5] and those of others [6, 7] to debunk these guesses, they continue to permeate the lay press. If you Google “third leading cause of death,” you will find countless headlines naming medical error.

The papers claiming medical errors cause so many deaths assume that all complications result from errors and all complications are preventable. They extrapolate their final numbers from small studies not designed to or capable of estimating deaths due to medical error nationwide.

The most recent figures available from the National Hospital Discharge Survey [8] state that the number of hospital deaths dropped from 776,000 in the year 2000 to 715,000 in 2010. It is simply not plausible that 251,000 (35%) or 440,000 (61%) inpatient deaths are due to medical error.

A recent study [9] from Norway found that of 1000 consecutive in-hospital deaths reviewed, only 42 (4.2%) were judged to be probably (greater than a 50% chance) to definitely avoidable.

Causes of death among residents

What is the leading cause of death among residents in all specialties?

A. Accidents
B. Neoplasms
C. Suicide
D. Miscellaneous diseases

If you answered C, you were wrong. The correct answer is B, neoplasms. Suicide was the second most common cause, followed by accidents and miscellaneous diseases.

A study in Academic Medicine looked at resident deaths over a 15 year period and found that of the 381,614 individual physicians in ACGME training programs, 66 died of suicide. For the over 1.6 million person-years studied, the suicide rate for residents was 4.07 per 100,000 person-years—well below the figure of 13.07 per 100,000 years in the general population of people aged 25-34.

Residents in age groups 35-44 and 45-54 had suicide rates higher than the 25-34 group and higher than the rates of those in comparable general population age groups.

More suicides occurred during the first and second years of training and during the months of July through September and January through March. In my opinion, the months that deaths occurred in can be explained as follows. In the first three months of the academic year, residents in the first and second years may feel overwhelmed and subject to self-doubt—the so-called "impostor syndrome." By the time January and February roll around, it is mid-winter, and it seems like the year will never end.

Residents had a much lower rate of death from accidents, including those related to automobile crashes, than the general population.

The overall death rate from all causes was also lower for residents than the rate of the general population at 16.91 per 100,000 person-years and 105.4 per 100,000 person-years, respectively.

The authors were surprised that resident rates of suicide were lower than age- and gender-matched populations especially because suicide rates for medical students and practicing physicians are higher.

They concluded that suicide was probably the only area in which prevention strategies, such as a supportive environment and medical and mental health services, could reduce the death toll.

Program directors, faculty, and residents themselves should probably show heightened vigilance in the first and third quarters of the academic year particularly for first and second year trainees.

Good patient safety news you didn’t hear about

In the last five years, there’s been a 21% reduction in hospital acquired conditions (HACs) says a report by the Agency for Healthcare Research and Quality. This means that patients suffered 3.1 million fewer HACs than if the HAC rate had stayed at the 2010 level.

Since 2011, the decrease in HACs has reduced healthcare costs by an estimated $28.2 billion and has saved almost 125,000 lives.

This graphic summarizes the AHRQ findings.

Central line-associated bloodstream infections have fallen by 91%, and postoperative venous thromboembolism by 76%. Here’s a chart that shows the percent decreases in HACs.

The report said the reasons for these improvements “are not fully understood,” but might be due to the following:

• Financial incentives created by the Centers for Medicare & Medicaid Services (CMS) and other payers’ payment policies,
• Public reporting of hospital-level results,
• Technical assistance offered to hospitals by the Quality Improvement Organization (QIO) program, and
• Technical assistance and catalytic efforts of the HHS PfP [[Pay for Performance] initiative led by CMS.

An thorough Google search found a few articles about this important and positive AHRQ report. Were they in the New York Times, Washington Post, Newsweek, US News, or The Daily Mail?

No. the news could only be found on HealthcareIT Analytics, Fierce Healthcare, the website of the Healthcare Association of New York State, Pharmacy Practice News, and HealthcareIT News where I obtained the multicolored graphic above.

Why do you suppose no major media outlet reported the story?

Good news doesn’t get clicks.

Deciding whether adverse events are preventable or not

Adverse events and poor outcomes are not always preventable. Deciding whether an adverse event is preventable or not can be difficult.

"To Err is Human: Building a Safer Health System," the original Institute of Medicine report in 1999, stated that  between 44,000 and 98,000 deaths each year were caused by preventable medical errors.

That report was widely cited and spawned a number of studies and reviews claiming that anywhere from 250,000 to 440,000 preventable deaths occur in the United States every year.

I was critical of the 440,000 deaths paper as well as the most recent of these estimates—the one claiming 250,000 deaths due to medical errors per year.

It's not widely known or perhaps simply forgotten, but the 1999 Institute of Medicine report also came under fire. In 2000, two researchers from Dartmouth, Drs. Harold C. Sox Jr, and Steven Woloshin, published a critique called "How many deaths are due to medical error? Getting the number right."

When bad research is not critically reported by journalists

Yesterday I posted a critical review of the study "Medical error—the third leading cause of death in the US."

I did not have time to address the media coverage of the paper, but fortunately the website HealthNewsReview did.

Their post started with "Seemingly all the major outlets carried the story, with headlines so alarming that they’d have any conscious hospital patient demanding an immediate discharge."

They called attention to headlines which included the word "now" such as these:

CBS: Medical errors now 3rd leading cause of death in U.S., study suggests
Washington Post: Researchers: Medical errors now third leading cause of death in United States
Nature World News: Medical Errors Now the Third Leading Cause of Mortality in U.S.

They pointed out that the headlines were similar to the title of a press release issued by the PR department at Johns Hopkins and that using "now" in the headline implies that the incidence of deaths caused by medical error has increased.

Are there really 250,000 preventable deaths per year in US hospitals?

For the last couple of days, the Twitter medical community has been discussing the latest in a long line of papers attempting to estimate the role of medical error as a cause of death.

This week's entry appeared in the BMJ (full text available here) and was by a surgeon at Johns Hopkins, Dr. Martin Makary, who claims that 251,454 patients die from medical error every year.

Makary's review extrapolated that figure from three papers published before 2009 which had a combined 35 supposedly preventable deaths. That's not a typo—35 deaths in all. One of the papers stated that all 9 deaths in three tertiary care hospitals were preventable. In his BMJ paper, Makary says, "some argue that all iatrogenic deaths are preventable."

I disagree. I have analyzed other papers on this subject and pointed out that certain complications and deaths are not 100% preventable. For example, no study of deep venous thrombosis and pulmonary embolism shows total efficacy of any prevention strategy. And some patients will suffer myocardial infarctions and die even when they are properly treated.

In this month's BMJ Quality and Safety, Dr. Helen Hogan of the Department of Health Service Research and Policy at the London School of Hygiene and Tropical Medicine discusses the problems associated with using preventable deaths as a measure of quality.