Showing posts with label IV fluid. Show all posts
Showing posts with label IV fluid. Show all posts

Thursday, October 16, 2014

Lactated ringers and hyperkalemia: A blog post meriting academic credit

In a recent post, I suggested that physicians should receive academic recognition for certain social media activities. "Myth-busting: Lactated Ringers is safe in hyperkalemia, and is superior to NS," written by Dr. Josh Farkas (@PulmCrit), is a great example of why that is true.

Using only about 1250 words and 6 references, he explains that infusing lactated ringers not only does not cause harm, it is actually superior to normal saline in patients with hyperkalemia, metabolic acidosis, and renal failure.

I highly recommend reading the post which should take you only a few minutes. If you're too lazy to do that, here's a summary.

Dr. Farkas found no evidence that lactated ringers cause or worsens hyperkalemia. In fact, he presents some solid evidence to the contrary.

If the serum potassium is 6 mEq/L, a liter of lactated ringers, which contains 4 mEq/L of potassium, will actually lower the potassium level.

Because almost all potassium (~98%) in the body is intracellular, the infusion of any fluid with a normal potassium content will result in prompt redistribution of potassium into the cells negating any of the almost negligible effect of the potassium infusion.

A normal saline infusion is acidic, resulting in potassium shifting out of cells and increasing the serum potassium level. Lactated ringers, containing the equivalent of 28 mEq/L of bicarbonate, does not cause acidosis.

There's a lot more in the post. Read it.

This issue is arguably the most misunderstood fluid and electrolyte concept in all of medicine.

In my opinion, the post should be displayed on the bulletin boards of intensive care units, emergency departments, and inpatient floors of every hospital in the world and should be read by every resident or attending physician who writes orders for IV fluids.

Disclosure: I've never been a fan of normal saline. Two years ago I wrote a post that discussed two papers showing that because of its negative effects on renal function, normal saline was inferior to lactated ringers in critically ill patients.

Thursday, October 18, 2012

Is normal saline bad for the kidneys?



Answer: Yes.

This week, the two heavyweight medical journals, JAMA and the New England Journal of Medicine, featured papers describing the effect of certain intravenous fluids on the incidence of renal failure in critically ill ICU patients.

The JAMA paper compared normal saline (relative to human plasma, a high chloride-containing solution) administration to more physiologic, low chloride-containing IV fluids such as Hartmann’s solution (very similar to Ringer’s lactate) or Plasma-Lyte 148. It showed that using the low chloride intravenous infusions led to a statistically significant decrease in the incidence of acute kidney injury and the need for renal replacement therapy.

The NEJM paper compared the use of intravenous hydroxyethyl starch (HES) fluid resuscitation to normal saline and found that patients given HES had significantly more acute kidney injury and needed more renal replacement therapy. Bear in mind that HES is actually a solution of 6% HES in normal saline.

Neither study found a significant difference in mortality rates related to the various solutions used.

Both studies were performed in Australia during different time periods. The JAMA paper was based on research from a single hospital in Melbourne in 2008-2009 and was a before-and-after trial while the NEJM study was multi-institutional, randomized and prospective and took place from December 2009 to January 2012.

Is normal saline bad for the kidneys? Yes. If you compare high chloride normal saline to lower chloride solutions, normal saline causes more renal dysfunction and need for renal replacement therapy. Normal saline vs. HES really compared normal saline alone to 6% starch in normal saline, and showed that the starch is probably the factor causing renal injury.

So what is a clinician to do? Normal saline is not really “normal.” Solutions containing amounts of chloride closer to that of human plasma are the correct ones to use. As we surgeons have maintained all along, Ringer’s lactate should be the resuscitation fluid of choice in the U.S.

See the table below for the amounts of sodium, chloride and buffer in standard IV solutions.